San Francisco 49ers 2025 Opponents List. With the 49ers losing to the lions on monday night, the cardinals clinched third place in the nfc west. The 2024 season has been ugly for the san francisco 49ers, and a brutal schedule hasn't helped.

To close out the season, they will attempt to patch together an offensive line. We’ll have an eye on the nfl draft order down the stretch, but it’ll also be worth watching the division standings.